- Reigate Grammar School (2005-2012) A-levels in Maths, Further Maths, Biology, Chemistry and Physics.
- MBiochem at Brasenose College, University of Oxford (2012-2016)
- MRC iCASE student as part of the Interdisciplinary Bioscience DTP (2016-) , working with Genentech and studying at Magdalen College.
My academic interests lie in how protein structure is intimately coupled to function. Specifically I am interested in how TREK-1 and TREK-2 of the K2P family of Potassium Channels are gated, and how we can modify this for a potential therapeutic for chronic pain. They show a polymodal activation from a diverse array of stimuli, from small molecules to membrane stretch, and it is difficult to imagine that the structural changes resulting from each of these stimuli are identical. We currently have crystal structures of these channels in an array of different conformations and I am using a nanbody based approach to attempt to find state-dependent inhibitors which will allow us to functionally characterise the different conformations.
- DPhil 'Mechanisms underlying small molecule regulation of K2P ion channel activity for the treatment of pain'
- Part II (Integrated Masters) ‘Investigation of how Apolipoprotein LI (ApoLI) of the human innate immune defence against trypanosomes binds to membranes and how Serum
Resistance Associated Protein (SRA) inhibits ApoLI action’ Professor Matthew
Higgins, Department of Biochemistry, Oxford
- Summer project ‘Optimisation of crystal packing contacts in Serum Resistance Associated (SRA) protein of Trypanosoma brucei rhodesiense’ Professor Matthew Higgins,
Department of Biochemistry, Oxford
- Summer Project ‘Identification of transcripts made by alternative R-loop RNA Pol II promoters’ Professor Nicholas Proudfoot, Sir William Dunn School of Pathology, Oxford