Sophie Williams

Personal photo - Sophie Williams

Sophie Williams

Doctoral Student at the

Rex Richards Building, South Parks Road, Oxford OX1 3QU


I am a BBSRC funded Interdisicplinary Biosciences DPhil student at the University of Oxford. My interests are in applying structural biology approaches to understand the mechanistic detail of protein interactions and protein folding underlying human health and disease. I completed my BSc in Biological Sciences at the University of Leeds where I studied molecular and cellular biology, and biochemistry.


University of Oxford

DPhil Interdisciplinary Biosciences

University of Leeds

BSc (Hons) Biological Sciences


Project at Research Complex at Harwell

Rutherford Appleton Laboratory, Harwell Science Campus

Worked in X-ray crystalography and structural biology group focused on protein-nucleic acid complexes. This project aimed to study the protein machinery that controls plasmid replication in bacteria.

Undergraduate Dissertation project

University of Leeds

Artificial disc replacement is a type of joint replacements which involves putting a prosthetic intervertebral disc into the spine. These joint replacements, as well as other types, will produce wear particles as the patient moves. It is unknown what effect these particles will have on the tissue surrounding the joint replacement. My project was to investigated the immunological effects of wear particles produced by intervertebral disc replacements on the membrane surrounding the spinal cord.

Wellcome Trust Biomedical Vacation Scholarship

University of Leeds

The JC polyomavirus is a very common human polyomavirus that is known to cause progressive multifocal leukoencephalopathy in immunocompromised patients. This disease has a high mortality rate and has no specific treatment, so this project aimed to characterise the agnoprotein from JC polyomavirus in order to further understand viral pathogenesis.