Andrew Wiles Building
Radcliffe Observatory Quarter
I have a maths & engineering background. During my last year of my undergraduate I discovered the fascinating world of applied mathematics in cancer biology. I joined the Industrial Doctorate Centre DTC programme in order to broaden my horizons and to get to know the variety of research fields falling under the "systems biology" approach. My DPhil project will allow me to gain an insight on the biology of the problems, while improving my mathematical modelling knowledge.
Second 10-week short project at the Computational Science lab - Microsoft Research - Cambridge.
Ten weeks research project in the Computational Science department under the joint supervision of Dr. Drew Purves (head of the CEES CEES group at Microsoft) and Dr. James Osborne (University of Oxford and Microsoft Research). I developed motion models for individual particles at the cell's scale. The very same techniques can be translated to animal movement/migration. I applied Bayesian inference for parameter estimation and model selection, with the aid of Filzbach, a tool developed in this MSR lab.
Project title: How do Cells Move? Motion Models and Parameter Estimation
Ten weeks research project in the Mathematical Oncology department under the supervision of Dr. Alexander R. A. Anderson (PI, IMO co-director). I developed a model aimed at describing Fibroblasts-mediated drug resistance in metastatic Melanoma. Interactions between cancer cells and stroma cells are described in the form of a dynamical system, which explores the cancer cells activation of the stroma and the contribution of the latter in resistance to treatments. One of the exciting outcomes of this model will be its application to treatment dosing and schedule optimization, especially in combination theraphy.
Project title: Fibroblast-mediated Drug Resistance in Melanoma
Mathematical oncology research under the supervision of Dr. Alexander R. A. Anderson (PI, IMO co-director) for my Master's thesis. First as a visiting scholar, later as a Research Associate, I developed continuum and hybrid continuum- discrete models of tumor invasion. Implementing finite difference methods and cellular automata algorithms. The focus was on developing an individual based model exploring the plasticity of stem-like behavior of cancer cells, the role of the microenvironment and the feedback between the two.
Thesis: The Role of Intratumor Heterogeneity and Microenvironment Selection in Tumor Initiation and Progression.
Short rotation experience at the Cardiology Department, under the supervision of Dr. Guido Pagana (Department of Control and Computer Engineering - Politecnico di Torino), aimed at the development of time-frequency analysis techniques aiding the disease prognosis and treatment of patients affected by atrial fibrillation.
Thesis: Atrial Fibrillation Treatment by Time-Frequency Analysis of the Bipolar Cardiac Signal.
MSc in Mathematical Modeling in Engineering - Politecnico di Torino
BSc in Mathematics in Engineering - Politecnico di Torino
I believe it's every human being's duty and privilege to keep an eye on the outside world. Getting to know an amazing, though struggling population, such the one living in the Cape Verde islands, was inspirational and definitely helped me to put things in perspective.
And, oh yes… I play the guitar!
M. J. Simpson, K. K. Treloar, B. J. Binder, P. Haridas, K. J. Manton, D. I. Leavesley, D. L. S. McElwain and R. E. Baker (2013). Quantifying the roles of cell motility and cell proliferation in a circular barrier assay. J. Roy. Soc. Interface. 10(82):20130007. pdf
M. M. Mueller, N. E. Fuesing (2004). Friends or foes - Bipolar effects of the tumor stroma in cancer - Nature Rewies Cancer 4, 839-849. pdf
R.A. Gatenby, R.J. Gillies (2004). Why do cancers have high aerobic glycolysis? Nature Rewies Cancer 4, 891-899. pdf