TISSUE ENGINEERING RESEARCH

The discovery of stem cells and the ways to manipulate them gave hope to a new era of cell based therapies, however only recently we have learned to to turn groups of cells into organ resembling structures - organoids. During the last few years many organoids have been created for mimicking heart, brain, intestine, eye or ear tissues and opening new possibilities for high throughput drug testing and reducing animal use. However creating an accurate and reproducible representation of naturally occurring tissues requires an in-depth understanding of developmental biology, as well as the tools to manipulate organoid composition and shape. My DPhil project aims to create new tools for the relatively young area of tissue micro-manipulation in order to understand how their shape controls development.

prof. Fritz Vollrath lab

Controlling tissue shape

In order to understand the role of tissue geometry during development we must be able to define it in a controllable manner. My main research area focuses on reshaping microscopic tissues.

3D image analysis

Routine confocal microscopy is a very data rich source, provided it can be extracted in an automated fashion. Using ImageJ, MatLab and C++, I develop new methods to quantify proteins in developing tissues at sub-cellular resolution.

prof. Shankar Srinivas lab
prof. Shankar Srinivas lab

Statistical modelling

To demonstrate how tissue geometry affects individual cell decisions and test underlying mechanisms I use decision tree based modelling (RandomForests) to predict how cell environment will determine their fate.

Hardware design

I consider myself lucky, that my hobby of hardware electronics and programming could be easily integrated into my bioengineering career. Apart from allowing me to create tools for my research, I had a pleasure of designing a medical device for HingeHealth and working in COPE clinical trials as a technician with novel organ perfusion devices.

COPE clinical trials

HingeHealth

Tools for research

GET IN TOUCH

Please feel free to email me at: firstname.lastname@seh.ox.ac.uk. There is also more information available on my LinkedIn