Keble College, University of Oxford
- DPhil: "Generic Synthetic Approaches for Elaborating Binding Site Chemistry Identified from Crystal Structures with Bound Fragments", Medicinal Chemistry and Chemical Biology Group, SGC.
- SABS-IDC - System Approaches to Biomedical Science: Industrial Doctoral Centre, Sept 2012 - present. Module Timetable.
- MChem, Masters of Chemsitry, University of Oxford, Oct 2008 - June 2012.
- 4th Year Project: "Synthetic Investigations into tagged PIM1 Kinase Inhibitors", Angela Russell research group (see Work Experience & Research).
- Additional Modules: Quantum Mechanics for Chemists (Distinction), March 2010
. Chemical Pharmacology (Pass), March 2012.
- Awards: Prize for First Year Practical Organic Chemistry, June 2009. AstraZeneca Organic Chemistry Bursary, Dec 2009 - June 2012.
From 2001 until 2008 I attended Chew Valley School, where I completed my GCSEs and A-Levels. At the age of 16 I specialised in maths, physics, chemistry and geography. After receiving an offer from Oxford to study chemistry I attained A-Levels in Maths, Further Maths, Physics and Chemisty.
Work Experience & Research
- DPhil research project in fragment library design and fragment screening using x-ray crystallography with Dr. Paul Brennan (SGC) and Professor Frank von Delft (SGC & Diamond Light Source). The project investigates the design, purchase and testing of a chemically poised fragment library which would allow for rapid hit-to-lead optimisation. Hit discovery will be performed using high throughput x-ray crystallographic screens. The library is to be designed to allow elaboration via reliable, one-step chemistry using commercially available starting materials. Fragment elaboration will be guided by hit crystallographic data and docking studies. Oct 2013 - present.
- Completed a 10-week short project entitled Generic Synthetic Approaches for Elaborating Binding Site Chemistry Identified from Crystal Structures with Bound Fragments with Dr. Paul Brennan. Preliminary investigations into the design of a chemically poised fragment library. A fragment-like library was built from the ZINC database (www.zinc.docking.org) and analysed using the Schrodinger Suite for Knime. Reliable and versatile reactions regularly used in medicinal chemistry were chosen to perform fragment deconstruction. Reactions chosen include amide couplings, sulfonamide couplings and Sonogashira Couplings. Summer 2013.
- Completed a 10-week short project entitled Combining ITC with Simulation to Improve Drug Discovery with Dr. Phil Biggin & Prof Stefan Knapp. The use of isothermal titration calorimetry (ITC) and molecular dynamic simulations to investigate how the free energy of binding effects ligand binding. ITC was performed on the BRD4(1)/PFI-1 system. MD simulations were performed using Gromacs software on BRD4(1) crystal structures. Summer 2013.
- Part II (4th Year) Project with Angela Russell in the CRL, involving the rational design of tagged PIM1 inhibitors. The project aimed to modify a potent and selective inhibitor developed within the Russell group such that it could be labelled with a florescence tag or a solid support scaffold. This in turn could aid the study and isolation of PIM1, a kinase implicated in the development of cancer. The project combined SAR data with rational design and GOLD software docking studies to synthesise potent inhibitors that were tested in the Pharmacology Department using PIM1 assays developed within the group.
- Completed a 10-week placement at AstraZeneca Alderley Edge site synthesising a range of amines that were used to obtain Structure Activity Relationship (SAR) data of a lead compound in drug development, Summer 2011.