Doctoral Student at the
New Biochemistry Building, South Parks Road, Oxford OX1 3QU
BSc(Hons) in Biochemistry, University of Edinburgh, UK
MRes in Structural Biology and Molecular Biophysics, University College London, UK
I am fascinated by how proteins work together in molecular assemblies. Since insights into such information are limited by the available technology, to understand how a large protein complex goes about to carry its function, we merge multiple structural techniques, and combine them with approaches from biochemistry, computational biology and cell biology. Such integrated research requires collaboration between many labs and people. We are working together to address a basic science question: how a centrosome is assembled from parts?
Palumbo V, Pellacani C, Heesom KJ, Rogala KB, Deane CM, Mottier-Pavie V, Gatti M, Bonaccorsi S, Wakefield JG. (2015) Current Biology, Misato Controls Mitotic Microtubule Generation by Stabilizing the Tubulin Chaperone Protein-1 Complex.
Rogala KB, Dynes NJ, Hatzopoulos GN, Yan J, Pong SK, Robinson CV, Deane CM, Gönczy P, Vakonakis I. (2015) eLife, The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation.
Bagnéris C, Rogala KB, Baratchian M, Zamfir V, Kunze MB, Dagless S, Pirker KF, Collins MK, Hall BA, Barrett TE, Kay CW. (2015) Journal of Biological Chemistry, Probing the Solution Structure of IκB Kinase (IKK) Subunit γ and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit β by EPR Spectroscopy.
Hatzopoulos GN, Erat MC, Cutts E, Rogala KB, Slater LM, Stansfeld PJ, Vakonakis I. (2013) Structure, Structural analysis of the G-Box domain of the microcephaly protein CPAP suggests a role in centriole architecture.