DTC Short Projects
- Project 1: "Automated Assessment and Minimising Variations in PET-CT Quality Control Data" with Dr Vicente Grau and Dr Ed Sommers (from GE Healthcare). The project involved developing an image processing technique to minimise variations in analysing phantom data from multi-centre clinical trials, by automatically selecting regions of interest and generating recovery coefficient (RC) curves.
- Project 2: "Assessing Crystallizability of Proteins from Crystallization Experiments without Crystals", which is also now my DPhil. project.
- "Precipitation Behaviour as a Proxy for Protein Crystallization", with the Protein Crystallography (PX) Group at the Structural Genomics Consortium. I am supervised by Dr Frank von Delft, Dr Michael Osborne and Prof Stephen Roberts , as well as Dr Carrien Dekker and Dr Markus Kroemer as my industrial supervisors from Novartis, Basel.
- The project applies machine vision techniques and machine learning algorithms on crystallization experiments to objectively characterize precipitation behaviour, and infer an experiment's crystallizability from its collective precipitation behaviour. We have shown that a typical crystalliation screening experiment with sparse-matrix screens can serve as an assay of a protein, where knowledge-based approach can be used to identify potential chemical space for finer follow-up experiments.
- "Spin-off" projects include ranking crystallization droplets for more efficient viewing and assessing experiments. A software package, TeXRank, which consists of the image processing pipeline and calculation of ranks and a viewer for the presentation of the algorithm's output is available here.
- Clear-drops as solubility screens, where we used the trends of change in precipitation across sub-wells with different protein to precipitant mixing ratio in sparse-matrix screens to identify chemical components that appear to stabilize and solubilize a protein. These components can be used for reformulating the protein for more stable and soluble sample (pending publication).