Cellular Design 1

This module will introduce some of the concepts, technologies and techniques, which can allow the design and engineering of novel cellular functionality. The week will begin with lectures on flux in metabolic networks, describing the process of going from analysis to manipulation and engineering metabolism. This will be followed by Gene Cluster Discovery and Combinatorial Engineering of Metabolism. Lectures on Directed Evolution as a tool will introduce the basic notions and the use of evolution as a design tool in synthetic biology.. Lastly, this module will cover genome minimization and advanced genome editing. (Duration: one week)